5, 6, 8, 9, 10 Subsequent studies that applied advanced imaging and analytical techniques to the regional gray-matter (GM) and white-matter (WM) volumes and cortical thickness have revealed focal alterations of the volume and cortical thickness mainly in frontotemporal and parietal regions. 5, 6, 7, 8, 9, 10 Previous quantitative neuroimaging studies of brain subcortical structures have shown altered volumes of the thalamus or amygdala in patients with CAE. Recent studies using advanced magnetic resonance imaging (MRI) techniques have revealed that patients with CAE have focal structural abnormalities that are not detected using routine MRI. 3 Although CAE usually has a favorable prognosis, psychiatric problems such as attention deficit/hyperactivity disorder (ADHD) as well as behavioral problems may occur and persist even in the absence of ongoing seizures. 1, 2 The onset of seizures occurs between the ages of 4 and 8 years, with spontaneous remission around adolescence, and this age-dependent onset and remission means that CAE is regarded as a developmental disorder. Childhood absence epilepsy (CAE) is a common generalized epilepsy syndrome with a presumed genetic cause that is characterized by frequent daily absence seizures, with electroencephalography (EEG) showing bilateral, synchronous, symmetric spike-and-wave discharges at approximately 3 Hz.
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Physical interfaces facilitate gameplay yet constrict game design practice and constrain physiological accessibility. Character configuration can allow players to customize their experience, but limits in the design of customization can limit who games can be about. Authentication secures access control while enrolling players in data-driven practices that are increasingly commonplace in computational media. These interfaces set the stakes for what gameplay can be and demand players conform to implicit and explicit norms in return for access to gameplay. Interfaces like these dictate accessibility and inclusivity and influence how players interact with games. In this dissertation, I critically examine everyday transactions of authority and value in the design of digital games by calling attention to interfaces and interactions on the periphery of gaming such as authentication, character configuration, and physical interfaces. When encountering a new digital game, players can rarely access gameplay without first installing and patching the game, assenting to its End User License Agreement, creating an account, or adjusting the audiovisual and gameplay settings. It's possible to beat the crap out of the AI by using the same move over and over again. Having to actively block one type of attack, but passively block the other isn't even consistant within the game. Every fighting game since blocking was invented has forced the player to actively block. The move to block high is to do nothing, but to block low you must pull down. So you have to complete the game 13 times to get them all. It may have 21 characters, but 13 of them are hidden. It may just be that it doesn't compare favourably with arcade games) (The following rampant criticism is based on the PSX version. How can anybody like this game? 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